无边的戈壁滩上,欠下高利贷的二勇(王学兵 饰)意外与来历不明的孩子尕娃(朱耕佑 饰)踏上了一段凶险的追妻之旅,笔直又狭长的公路上,二勇和尕娃与忧郁暴躁的女卡车司机小眉(马伊琍 饰)相遇,三个性格迥异的人因故临时结伴而行,在穿越戈壁的三天两夜里,三个孤独的人度过了一段恍若家人的时光。随着旅途的继续,他们邂逅的人和遭遇的事,使得每个人命运发生了重大改变,人的命,路的头,在苍茫天地之下都变得微不足道……In the depths of western China's Gobi Desert, Yong (Wang Xuebing) operates a dilapidated ostrich farm, which is the last throw of the dice for him as he tries to win back his ex-wife and repair his life. One day, Mr. Wu (Wang Xufeng) comes looking for a debt to be repaid. When Yong can't come up with the money, Wu leaves a lonely little boy (Zhu Gengyou) behind, telling Yong to look after him. Suspecting his ex-wife might be considering another marriage, Yong can only take the boy along as he goes to find her. In three days crossing the Gobi, they meet a sad and depressed female trucker Mei (Ma YiLi), and the three lonely people become a pseudo-family.More people join the action and the relationship between Yong and the boy is constantly tested and evolving over this journey. In the end, through these series of random encounters, every person embarks on their own path of no return.