鲍勃(大卫·杜楚尼 David Duchovny 饰)是一名建筑工程师,和妻子伊丽莎白(朱莉·理查德森 Joely Richardson 饰)结婚多年,两人之间感情非常的要好。然而,一场可怕的疾病夺取了伊丽莎白的生命,也夺取了鲍勃人生里所有的幸福和快乐。伊丽莎白生前非常的喜欢动物,因此,鲍勃决定完成妻子的遗志,帮助动物园的大猩猩建造屋舍。 格瑞斯(明妮·德里弗 Minnie Driver 饰)是一名平凡的餐厅服务员,在经历了一场成功的换心手术之后,格瑞斯开启了她的第二次生命。在命运的安排之下,人生已经结束的鲍勃邂逅了人生刚刚开始的格瑞斯,两人之间会碰撞出怎样有趣的故事呢?The film opens with a loving husband and wife preparing for a very important fund raising dinner. The evening ends with the loss of the wife. In a hospital a weak young woman who may die soon if she can not get a new heart. Jump ahead one year the young woman received a heart and is trying to adjust to a life no longer counted by hours or days, she can actually make plans. The grieving husband and his dog are still trying to adjust to life without his wife. His friends keep trying to pry him from his "work is my life" existence by setting him up on blinds dates. Finally he actually shows up for one at an Irish-Italian restaurant where he finds himself more attracted to the waitress than his blind date. He finds an excuse to return to the restaurant in hopes of seeing the waitress again, there's just something attractive about her. Unknown to both the attraction they both feel for one another is Grace has the heart of Bob's dead wife. What can you say after that! Carroll O'Connor says exactly the right thing to Bob after he finds out this ironic coincidence.