故事发生在天保14年的江户。当时在老中?水野忠邦实施的财政紧缩政策之下的老百姓生活在极度困扃中。国内government的压迫,加上外国殖民者入侵的威胁,在江户的大街小巷中弥漫着一种不安的气氛。在不为世人所知的地下,存在着一个秘密的神社。这个神社表面上对外称是对外国传入的学术文化进行研究调查的『蛮社改所』,而实际上则是专门对付各国潜入日本的『妖夷』,并负责将他们秘密抹杀的government隐蔽机关。该组织的头目名为小笠原放三郎,是个醉心于“兰学”,并极力证明其实用性的学者。然而却不得不听从南町奉行?鸟居耀藏的差遣。小笠原虽然没有了得的身手,但却与有着能将汉字中蕴藏的不可思议力量“汉神”诱导而出并具现化的高超能力的“妖奇士”龙导往压等人承担着暗中保护江户的职责...Feudal Japan is attacked by beasts called 'Youi'. Ryuudou Yukiatsu, a 'floater' and an employee at a bath house has the power of Ayagami ("The power to find the words behind things") which can be used in fighting against the Youi. That's why the members of a Youi-fighting group Bansha Aratamesho, called the Ayashi, are looking for Yukiatsu - they want him to become an Ayashi as well. Yukiatsu runs into a woman and a son who are chased by a Youi and has to face the past he's been running away from.
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