Nilalang is about an NBI agent who teams up with an heiress to a transnational organized crime syndicate in Japan to put a stop to the centuries molikan.com old curse that may be responsible for the spate of serial killings happening in Manila.NBI special crimes division agent Tony (Cesar Montano) encounters an evil entity which is bent on killing and torturing beautiful women, one of which was his girlfriend, years after he have thought to have killed the malevolent spirit. People close to Tony is in danger including his partner Jane (Meg Imperial), who has romantic interest towards him with everyone in the agency aware of this fact except for Tony. The spirit, who has killed many people in Japan, is thought to be targeting women from a certain clan of samurai. In Manila, Miyuki (Maria Ozawa) takes care of the family business while her younger sister is taking care of their aging father. Miyuki is later forced to help in the investigation regarding the murders after Akane went missing and their father was found dead to put of stop to the evil entity's killing spree.